APART from a yap out of proportion to their size, what do chihuahuas, terriers and pekinese have in common? The answer is a mutation in a single gene. The variant is found in so many small breeds that it must have been present early in the history of dogs' domestication.
A team led by Elaine Ostrander of the National Human Genome Research Institute in
The "small" variant of IGF1 is not known in wolves -- dogs' closest wild relative. "Perhaps man selected a small wolf that doesn't exist now, or they found a small variant that everybody liked," says team member Gordon Lark at the